常翠,杨宏图,董淳,毕殿洲
Chang Cui;Yang Hongtu;Dong Chun;Bi Dianzhou(Department of Pharmacy;

• 1:深圳市人民医院
• 2:深圳市人民医院
• 3:深圳市人民医院
• 4:沈阳药科大学药剂教研室 暨南大学第二附属医院药学部

摘要(Abstract)：

目的　介绍缓、控释制剂的体外释放度测定方法 ,使其能更好地模拟体内状态。方法　综述最近的中外文献中有关缓释、控释制剂的体外释放度测定实验方法 ,实验条件的选择及影响因素。结果　体外释放度实验条件如释放介质的 pH值、离子强度、增溶剂、表面活性剂和释放仪器等可影响缓、控释制剂的体外释放度。结论　根据不同药物选择尽可能接近体内状态的方法
Objective Introduce the in vitro dissolution testing method for sustained or controlled release dosage forms,so that the in vivo state can be better simulated.Methods Summarize all current literatures about experimental methods,the choice and influence factors of experimental condition of in vitro dissolution testing.Results The experimental condition like the pH value and ion intensity of release medium,solubilizers,surfactants,release apparatus and so on can effect the in vitro dissolution testing of sustained or controlled release dosage forms.Conclusion Choose the methods are likely to in vivo state according to different drugs.

关键词(KeyWords)： 体外释放度实验;缓释制剂;控释制剂;影响因素
experiment of in vitro dissolution testing;sustained or controlled release dosage forms;influence factor

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 常翠,杨宏图,董淳,毕殿洲
Chang Cui;Yang Hongtu;Dong Chun;Bi Dianzhou(Department of Pharmacy;

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