门诊老年患者镇静催眠药的临床用药分析Analysis of Clinical Application of Sedative-Hypnotics in Elderly Patients of Outpatients
肖逸丽,左桂莲,刘满芬
XIAO Yili,ZUO Guilian,LIU Manfen
摘要(Abstract)：
目的了解本院门诊老年患者镇静催眠药的使用情况。方法对本院2014-01~12老年患者使用镇静催眠药品的门诊处方进行回顾性统计分析。结果使用镇静催眠药的门诊老年患者处方共2 156张,以单用为主(94.20%),主要是苯二氮类药物占94.52%;用药频度前3位为艾司唑仑、阿普唑仑、劳拉西泮;除硝西泮外,统计药物的DUI≤1;用药时间≤4周者933张(43.27%),4周~3个月者907张(42.07%),≥3个月者316张(14.66%);主要用于精神分裂症668张(30.98%)、失眠症459张(21.29%)、抑郁症334张(15.49%)、焦虑症251张(11.64%)等。结论本院门诊老年患者镇静催眠药使用相对合理,部分患者使用时间偏长,临床用药应进一步加强规范。
OBJECTIVE To survey the use of sedative-hypnotics of elderly patients in the hospital outpatient. METHODS Retrospective statistical analysis of elderly patients was made with outpatient prescription sedative-hypnotics in the hospital from January to December,2014. RESULTS A total of 2 156 prescriptions of sedative-hypnotics for elderly patients were collected,and mainly were 1 kind of drug( 94. 20%),mainly benzodiazepines class( 94. 52%); Top 3 sedative-hypnotics in the list of DDDs were estzolam,alprazolam,lorazepam; In addition of the nitrazepam,the statistics of drug was DUI ≤1; 933 pieces( medication period ≤4 weeks)were accounting for 43. 27%,907 pieces( medication period between 4 weeks and 3 months) were accounting for 42. 07%,and 316pieces( medication period ≥3 months) were accounting for14. 66%; It was mainly used for 668 pieces of schizophrenia( 30. 98%),459 pieces of insomnia( 21. 29%),334 pieces of depression( 15. 49%),251 pieces of anxiety( 11. 64%),etc. CONCLUSION The use of sedative hypnotics is relatively reasonable for elderly patients of outpatients in the hospital,and the norms of long hours of clinical medicine for some patients should further be strengthened.
关键词(KeyWords)：
镇静催眠药;老年患者;药物利用指数;药物依赖
sedative-hypnotic;elderly patients;DUI;drug dependence
基金项目(Foundation):
作者(Author):
肖逸丽,左桂莲,刘满芬
XIAO Yili,ZUO Guilian,LIU Manfen
参考文献(References)：
- [1]陈新谦,金有豫,汤光.新编药物学[M].北京:人民卫生出版社,2003:219-220.
- [2]Melinda JB,Kenneth M,Greenwood,et al.Persistence of cognitive effects after withdrawal from long-term benzodiazepine use:a meta-analysis[J].Archives of Clinical Neuropsychology,2004,19:437-454.
- [3]邹豪,邵元福,朱才娟,等.医院药品DDD数排序分析的原理及利用[J].中国药房,1996,7(5):215-217.
- [4]李放,丁兆生,张晓斌.老年失眠患者门诊用药情况调查与健康教育指导[J].实用临床医药杂志,2012,16(14):99-102.
- [5]杨宝峰.药理学[M」北京:人民卫生出版社,2006:32-35.
- [6]邓家佩,翟长平,崔明.苯二氮类药在老年人群中的应用[J].临床精神医学杂志,2008,18(1):63-64.
- [7]卫生部.精神药品临床应用指导原则[S].卫医发〔2007〕39号.