今日药学

2013, v.23(09) 570-572

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注射用泮托拉唑在老年肝硬化患者药动学研究
Pharmacokinetic of Pantoprazole Injection in Elderly Patients with Liver Cirrhosis

简凤璧;周波;邹尚荣;
JIAN Feng-bi;ZHOU Bo;ZOU Shang-rong;Department of Pharmacy,The Eighth People's Hospital of Guangzhou;

摘要(Abstract):

目的研究老年肝硬化患者静脉滴注泮托拉唑的药动学特点。方法老年肝硬化患者单次静脉滴注泮托拉唑(40 mg),采用高效液相色谱法测定血浆中泮托拉唑浓度,采用DAS程序计算药动学参数。结果 5例受试者纳入研究,泮托拉唑半衰期为(5.57±3.64)h,清除率为(1.36±0.38)L/h,与健康人数据比较,泮托拉唑半衰期延长,清除率下降。结论老年肝硬化患者应用泮托拉唑可适当减少用量。
Objective To determine the pharmacokinetics of pantoprazole in elderly patients with liver cirrhosis. Methods The concentration of pantoprazole in plasma was tested by HPLC after a single dose infusion,and the pharmacokinetic paremeters were computed by DAS program. Results 5 patients participated in the study. The half-life of pantoprazole was( 5. 57 ± 3. 64) h and clearance was( 1. 36 ± 0. 38) L / h. The half-life was longer and clearance was lower than values in healthy volunteers. Conclusion The dosage of pantoprazole may be reduced for liver cirrhosis elderly patients.

关键词(KeyWords): 泮托拉唑;老年肝硬化;药动学
Pantoprazole;elderly patients with liver cirrhosis;pharmacokinetic

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基金项目(Foundation): 广东省医院药学研究基金(奥赛康基金)(编号:2012A17)

作者(Author): 简凤璧;周波;邹尚荣;
JIAN Feng-bi;ZHOU Bo;ZOU Shang-rong;Department of Pharmacy,The Eighth People's Hospital of Guangzhou;

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