陈卫,谢锦桃,张霖泽
CHEN Wei~1,XIE Jin-tao~1,ZHANG Lin-zhe~2(1.China Associate Pharmaceutical Co.

• 1:深圳市中联制药有限公司
• 2:深圳市中联制药有限公司
• 3:广州市医药工业研究所 广东深圳518004
• 4:广东深圳518004

摘要(Abstract)：

以盐酸二甲双胍为模型药物,以羟丙甲基纤维素及乙基纤维素为缓释骨架材料,制备相对刚性骨架缓释片。羟丙甲基纤维素、乙基纤维素、乳糖用量是影响缓释效果的主要因素。
Sustained-release Tablets is prepared using metformin hydrochloride as model drug,soluble HPMC and insoluble ethylcellulose as sustained material.The results showed that phamarcokinetic characteristics was very similar between Metformin Hydrochloride Sustained-release Tablets and GLUCOPHAGE XR.Two formulations were bioequivalent.

关键词(KeyWords)： 盐酸二甲双胍;缓释;释放度;生物等效性试验;众氏得
metformin hydrochloride;Sustained-release;bioequivalent.

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 陈卫,谢锦桃,张霖泽
CHEN Wei~1,XIE Jin-tao~1,ZHANG Lin-zhe~2(1.China Associate Pharmaceutical Co.

参考文献(References)：

• [1]王明学,李以欣,欧阳泰,等.“十五”及2015年医药科技发展规划背景资料汇编[M].北京:国家经济贸易委员会医药司,2000:650-655.
• [2]www.FDA.gov:G lucophage XR说明书[EB/OL].