今日药学

2011, v.21(03) 138-141

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中药治疗缺血性中风的药理研究进展
Pharmacological Study Progress of Traditional Chinese Medicine for Treatment of Ischemic Stroke

陈剑梅;郭洁文;潘竞锵;
CHEN Jian-mei,GUO Jie-wen,PAN Jing-qiang (Guangzhou Hospital of Traditional Chinese Medicine,Guangzhou,Guangdong 510130,China)

摘要(Abstract):

主要综述近3年中药治疗缺血性中风的药理研究进展。中药治疗缺血性中风的作用机制主要是通过抗脂质过氧化、降低兴奋性氨基酸毒性、调节脑组织一氧化氮(NO)含量和NO合酶活性、减轻细胞内钙超载、抑制细胞凋亡、抗炎等6个方面拮抗脑缺血再灌注损伤的病理生理改变。指出目前仍存在观测指标单一、涉及脑细胞功能恢复及脑神经功能重建等的研究有待深入,亟需建立病症结合、行业认可的标准的缺血性卒中动物模型,丰富研究指标,为总结与提高中医药治疗缺血性中风的临床疗效提供理论与实验依据。
To review the pharmacological study progress of traditional Chinese medicine(TCM) for the treatment of ischemic stroke(IS) in the recent 3 years.The mechanism of TCM for antagonizing the pathologic and pathophysiologic changes of cerebral ischemia reperfusion injury(CIRI) is related to 6 aspects,including resist lipid peroxidation,decrease toxicity of excitatory amino acid(EAA),regulate the levels of nitric oxide(NO) and vitalities of nitric oxide synthase(NOS),decrease intra-cellular calciumion content,inhibit apoptosis and anti-inflammatory effect.But the observation indexes were single.The researches which involve the recovery of the cerebral cells function and the reconstruction of the cranial nerve function need to be studied further.A standard IS animal model which can combine syndrome with disease and is accepted by medical practitioners need to be established,and the the observation indexes should be enriched,in order to provide theoretical and experimental base for increasing the clinical effectiveness for IS treatment.

关键词(KeyWords): 中药;缺血性中风;脑缺血再灌注损伤;氧自由基;兴奋性氨基酸;一氧化氮;细胞凋亡
traditional Chinese medicine;ischemic stroke;cerebral ischemia reperfusion injury;oxygen free radical;excitatory amino acid;NO;apoptosis

Abstract:

Keywords:

基金项目(Foundation): 广东省社会发展领域科技计划项目(编号:2008B030301266);; 广东省中医药管理局基金(编号:2007210);; 广州市中医药中西医结合科研(编号:2007A07)

作者(Author): 陈剑梅;郭洁文;潘竞锵;
CHEN Jian-mei,GUO Jie-wen,PAN Jing-qiang (Guangzhou Hospital of Traditional Chinese Medicine,Guangzhou,Guangdong 510130,China)

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