路筱涛,祝晨蔯
LU Xiao-tao;ZHU Chen-chen (Guangzhou Office of Xian-Janssen Pharmaceutical Ltd. ;

• 1:西安杨森制药公司广州办事处
• 2:广州中医药大学中药学院 广州 510095
• 3:广州 510405

摘要(Abstract)：

目的研究苦参碱降血脂的药理作用。方法 观察本品对小鼠高胆固醇症、大鼠及家鸽高血脂症的影响。结果 与对照组相比,苦参碱100 mg/kg、200 mg/kg,对75％蛋黄乳液所致小鼠高血脂症模型中,血清胆固醇的抑制率分别为23.7％、28.3％;并能显著降低高脂饮食所致大鼠及家鸽的血清胆固醇及甘油三酯水平;从家鸽的组织病理学检查表明,苦参碱组对高脂饮食所致家鸽的肝及主动脉的改变较时照组轻。结论 本品能够降低血脂,预防动脉粥样硬化。
Objective To study the lipid-lowering effects of matrine in mice,rats and pigeons. Methods The effects of matrine on the hypercholesterolemia were observed in mice, the hyperlipemia of rats and pigeons. Results In mice with hypercholesterolemia induced by 75% galacl-yok by intraperitoneal injection, 100 mg/kg and 200 mg/kg . Matrine could reduce the Teh 23.7% and 28.3% respectively (P <0.05). In rats and pigeons with diet-induced hyperlipemia, Matrine significantly reduced the Teh and the TC. At the same time, the changes of histopathology in heap and aorta of pigeons were milder than that of control group. Conclusion Matrine can decrease blood lipid and prevent atherosclerosis.

关键词(KeyWords)： 苦参碱;胆固醇;甘油三酯;动脉粥样硬化;病理组织学;小鼠;大鼠;家鸽
matrine; cholesterol; triglyceride; atherosclerosis; histopathology; mice; rats; pigeons

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 路筱涛,祝晨蔯
LU Xiao-tao;ZHU Chen-chen (Guangzhou Office of Xian-Janssen Pharmaceutical Ltd. ;

参考文献(References)：

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