今日药学

2022, v.32(03) 190-193+205

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中医药干预COVID-19肺炎动物模型的探讨
Discussion of the Animal Models for Intervention of Traditional Chinese Medicine on COVID-19

潘卫松;张婷;刘海鑫;陈蓉;
PAN Weisong;ZHANG Ting;LIU Haixin;CHEN Rong;Wuhan Institute for Drug and Medical Devices Control;National Medical Products Administration Key Laboratory of Quality Research and Control of Pharmaceutical Preparations;Murad Research Center for Modernized Chinese Medicine,Institute of interdisciplinary integrative medicine research,Shanghai University of Traditional Chinese Medicine;

摘要(Abstract):

目的 阐明中医药有效防止新型冠状病毒肺炎(COVID-19)患者转化为危重症的作用机制,为建立中医药治疗COVID-19生物评价平台建立应用基础。方法 综述了近年来报道的COVID-19动物模型和病理生理研究进展。结果 发现直接用冠状病毒感染的动物模型均不易转化为重症甚至濒死症状,且存在生物安全风险,而用脂多糖(LPS)诱导的急性肺损伤模型与COVID-19患者的临床危重症病理生理反应较为接近。结论 脂多糖(LPS)诱导的大鼠急性肺损伤模型是现阶段对于中医药防治COVID-19进行研究较为理想的动物模型。
OBJECTIVE To clarify the mechanism of Chinese medicine to effectively prevent the transformation of COVID-19 patients into critical illness, and to establish an application basis for the establishment of a biological evaluation platform for the treatment of COVID-19 by Chinese medicine. METHODS This review summarized the research progress in animal models and pathophysiology of COVID-19 reported in recent years. RESULTS It was found that the animal models directly infected with coronavirus were not easily transformed into severe or even moribund symptoms, and had biosafety risks, while the acute lung injury model induced by lipopolysaccharide(LPS) was similar to the clinical pathophysiology of hospitalized patients with COVID-19.The pathophysiological reaction was relatively closed. CONCLUSION The rat model of acute lung injury induced by lipopolysaccharide(LPS) is an ideal animal model for the research on the prevention and treatment of COVID-19 by traditional Chinese medicine at this stage.

关键词(KeyWords): 新冠肺炎;新冠肺炎病毒;脂多糖(LPS);Toll样受体(TLR);动物模型,生物评价
COVID-19;SARS-CoV-2;lipopolysaccharide(LPS);Toll-like receptor(TLR);animal model,biological evaluation

Abstract:

Keywords:

基金项目(Foundation): 湖北省药品监督管理局科研项目(20200103)

作者(Authors): 潘卫松;张婷;刘海鑫;陈蓉;
PAN Weisong;ZHANG Ting;LIU Haixin;CHEN Rong;Wuhan Institute for Drug and Medical Devices Control;National Medical Products Administration Key Laboratory of Quality Research and Control of Pharmaceutical Preparations;Murad Research Center for Modernized Chinese Medicine,Institute of interdisciplinary integrative medicine research,Shanghai University of Traditional Chinese Medicine;

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